Abstract

ORGAN ON CHIP TECHNOLOGY

Hambir S. S.*, Asole S. D., Bhagawat P. G. and Andhale A. K.

ABSTRACT

In vitro grown cells are showing promise in assays for evaluating drug candidates' safety, effectiveness, and toxicity. These in vitro cell-based assays have two key uses in the drug development process: seed molecule investigation and safety assessment. They are intended to assess safety and toxicity in single organs, but the in vivo pharmacokinetics and pharmacodynamics of the drug candidates delivered have not been taken into account. As a result, an assessing ystem that connects cell cultures is necessary. As a result, the ADME-Tox culture system has been presented as an in vitro ADME-Tox culture system. This current review article discusses the benefits and drawbacks of organs on a chip, as well as their present availability and uses.

Keywords: Organs on a chip, seed molecule, ADME-Tox culture system, in vitro cell based assay.