Abstract

FORMULATION, EVALUATION AND OPTIMIZATION OF TASTE MASKED ZOLMITRIPTAN ORALLY DISINTEGRATING TABLETS PREPARED BY DIRECT COMPRESSION METHOD USING DIFFERENT SUPER DISINTEGRATING AGENTS.

S.Janakidevi*, K.V.Ramanamurthy

ABSTRACT

The present investigation deals with the formulation of Taste masked orally disintegrating tablets of zolmitriptan that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. It is a bitter drug, used in the treatment of migraine, in order to mask the taste of drug, and to get rapid action, with improved bioavailability, Taste masked orally disintegrating tablets were prepared. Amberlite IPR88 is a cation-exchange resin used to mask the taste by continuous sonication (about 6 hrs) method. Tablets were prepared by direct compression method using super disintegrants like crospovidone (F1 to F3), croscarmellose sodium (F4 to F6) and sodium starch glycolate (F7 to F9), designated as nine different types of formulations at different concentrations of 2%, 3% and 4% respectively. Tablets were evaluated for weight variation, thickness, disintegration time, drug content, in vitro dissolution, wetting time. Tablets containing crospovidone 4% (F3) exhibit quick disintegration time than others. The in vitro disintegration time of the optimized tablet was within 30 seconds and shows 100% release within 15 min. It follows first order release kinetics with diffusion mechanism.

Keywords: Oral disintegration, superdisintegrants, Taste masking, Bioavailability.