Abstract

ANTI-HISTAMINIC AND BRONCHODILATOR SCREENING OF ADATHODA VASICA LEAF IN RODENNT MODEL

Pooja Patel*, Dr. Satkar Prasad and Dr. Shailesh Kumar Ghatuary

ABSTRACT

The present study is intended to investigate the Study of anti-asthmatic activity of methanolic extract of Adhatoda vasica. The leaves of medicinal plant Adhatoda Vasica (500 gm) was collected locally from M.P. The results of the present study revealed anti histaminic actions of different extracts of plant Adhathoda vasica. In this study control group of animals showed convulsion during the first 3 min of the experiment. Prior treatment of Adhathoda vasica extract (100 and 200 mg/kg body weight) protected animals to significant extent from the development of asphyxia produced by histamine aerosol confirming that it has an antihistaminic activity. The role of histamine in asthma is well established. Methanolic extract of Adhathoda vasica significantly and dose dependently increased the time of PCT following exposure to histamine aerosols induced bronchospasm in guinea pigs as shown in table. Increased in the time of PCT was more against histamine aerosol following administration of Adhathoda vasica extract. To conclude, our study indicate that the extract of Adhathoda vasica exert significant antiastmatic effect in experimentally induced asthma in animal comparable to standard drug and provides pharmacological evidence for the traditional use of extract as anti asthmatic agents. In conclusion, the results of the present investigation suggest that, higher dose of extract has significant broncho dilator activity against histamine.

Keywords: Adhathoda vasica, bronchospasm, antihistaminic, bronchodilator.