Abstract

FORMULATION APPROACHES OF IMMEDIATE RELEASE TABLETS: A REVIEW

Shruti V. Raundal*, Avish D. Maru, Mitesh P. Sonawane, Sudarshan B. Borse, Mayur M. Sonawane and Vaishnavi S. Sake

ABSTRACT

Tablet is the well-known among all dosage form existing nowadays because of its convenience of self-administration and easy manufacturing and packaging. Sometimes immediate onset of action is necessary than conventional treatment in many patients. To overcome these drawbacks immediate release pharmaceutical dosage form has developed as alternative oral dosage forms. Immediate release dosage forms disintegrate rapidly after administration. The main approach used in development of tablets is the use of superdisintegrant, Tablet molding technique, Direct Compression technique, Granulation technique, Mass extrusion Technique that allows the tablet to disintegrate immediately after administration. The main approach to tablet formulation involves the use of superdisintegrants such as croscarmellose, sodium starch glycolate, and crospovidone, etc. This shortens the disintegration time and thus increases the dissolution rate of the drug. Rapid disintegration can occur due to the rapid uptake, expansion and breakdown of water from the medium and thus increased bioavailability. Immediate onset of action is sometimes considered necessary and immediate release tablets are the final choice. Today, this formulation can be considered as basic pharmaceutical products found mostly in overalls market.

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