Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING BUCCAL FILMS OF BILASTINE

Somnath Patil, Somasharan Kale*, Nilesh Desale and Nishigandha Waykule

ABSTRACT

Oral mouth dissolving film of Bilastine was prepared with the solvent casting method using synthetic polymer and PEG400 as a plasticizer. The prepared films were then evaluated for the various evaluation parameters such as physical appearance, thickness, folding endurance, in vitro disintegration, mechanical properties, surface pH, drug content uniformity, taste evaluation, in vitro dissolution test. The F6 formulation was found to be optimized and appropriate in its evaluation parameters than compared to other formulation. Mouth dissoloving film Bilastine showed folding endurance test 152-170, disintegration time 29-35sec, thickness 0.39-0.47mm, the % elongation 10.7-26.8, the maximum % drug release 98.36% in 30mins, drug content 97-98.41% and surface pH of 6.4-6.6. Mouth dissolving films of Bilastine can be considered suitable for the treatment of symptoms of allergies and where a quicker onset of action for a dosage form is desirable along with the convenience of administration.

Keywords: Mouth dissolving film, Bilastine, Synthetic Polymer, Solvent casting.