Abstract

ANTIULCEROGENIC AND GASTROPROTECTIVE ACTIVITY OF PLECTRANTHUS AMBOINICUS ON COLD RESTRAINT STRESS AND NSAID INDUCED GASTRIC ULCERS IN ALBINO RATS

Kavitha Ch. N.*, Dilip Raja K., Moharnab Pradhan and Karuna Choudhary

ABSTRACT

Plectranthus amboinicus (PA) has been used to treat many ailments including stomach ulcer disease in folk medicine in India, but its efficacy has not been validated. The present study was therefore carried out to investigate the antiulcerogenic & gastroprotective activity of hydroalcoholic leaf extract of PA in rats. The effect of PA extract on gastric ulcers in cold restraint stress & NSAID induced ulcer models was studied using doses of 200, 400 mg/kg. Esomeprazole, 20 mg/kg was used as the reference standard. Severity of ulcers, ulcer score, and ulcer index were measured. Data were analyzed using one-way analysis of variance followed by Dunnette‟s multiple comparison post hoc test, and probability values; p

Keywords: Antiulcerogenic activity, Gastroprotective activity, Plectranthus amboinicus, Cold restraint stress, NSAID induced ulcers, Ulcer score.