Abstract

DEVELOPMENT OF ELECTROCHEMICAL METHODS FOR THE DETERMINATION OF 6-MERCAPTOPURINE DRUG AND ITS ANALYTICAL APPLICATIONS

Keerti M. Naik and Sharanappa T. Nandibewoor*

ABSTRACT

The electrochemical behavior of 6-mercaptopurine (6-MP) drug at glassy carbon and gold electrodes has been investigated using cyclic, differential pulse and square wave voltammetric techniques. The anodic peaks were characterized and the processes were diffusioncontrolled in both the electrodes. In the range of 6.0 × 10-8 to 1.0 × 10-6 M, the current measured by differential pulse and square wave voltammetries presents a good linear property as a function of the concentration of 6-MP with a low detection limit 0.0055 & 0.0028 μg/mL. The proposed method was successfully applied to 6-MP determination in pharmaceutical samples and in human biological fluids.

Keywords: 6-mercaptopurine; glassy carbon electrode; gold electrode; electrochemical determination; oxidation