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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS: MAY ISSUE PUBLISHED

May Issue has been successfully launched on 1 May 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION

Dr. Yogesh Thorat*, Dr. Avinash Hosmani, Onkar Wale, Nitin Mane, Prachet Bagewadikar

ABSTRACT

UV Spectrophotometric Method Development and Validation for quantitative estimation of Ondansetron Hydrochloride (OND). UV Spectrophotometric method has been widely employed in the determination of individual components in a mixture of fixed-dose combinations. We aim to develop a spectroscopic method for estimation of the Ondansetron HCL in ternary mixture by using UV spectrophotometry. The method was validated as per ICH guidelines. The drug obeyed Beer’s law and showed a good correlation. It showed absorption maxima at 309 nm in simulated saliva. The recovery studies confirmed the accuracy and precision of the method. It was successfully applied for the analysis of the drug in bulk and could be effectively used for routine analysis.

Keywords: UV spectrophotometry, Ondansetron hydrochloride, Simulated saliva, Tablets.

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