Abstract

NATURAL POLYMER’S POTENTIAL ROLE IN THE ADVANCEMENT OF MULTIPARTICULATE SYSTEMS FOR ACTIVE TARGETING TO COLON

Kinjal Gandhi* and Rakesh Kumar Jat

ABSTRACT

Drug distribution to the colon has become more important for the treatment of local disorders connected with the colon. To transfer nondegraded materials to the lower gastrointestinal tract, they must first travel through the stomach, the upper intestine, and then exploit the properties of the colon to release the medications exclusively in this section of the digestive tract. The use of biodegradable polymers to achieve targeted drug release to the colon has a lot of potential. Natural polymers have a lot of attraction for drug administration since they have a lot of derivatizable groups, a wide range of molecular weights, different chemical compositions, low toxicity, and biodegradability. Polysaccharides are bacterial enzymes that can breakdown these natural polysaccharides in high enough numbers.

Keywords: Multiparticulates, Bioadhesive polysaccharides, colon.