Abstract

EVALUATION OF SOME BIOCHEMICAL PARAMETERS IN NEONATES FROM GESTATIONAL DIABETIC PREGNANCY

Ifetayo Helen Ajayi and Ajibade Oluwagbenga Oyeyemi*

ABSTRACT

Neonates from pregnant women with gestational diabetes mellitus (GDM) are predisposed to various risk factors that could lead to neonatal adverse outcome. The main objective of this study was to investigate the effect of GDM on some biochemical parameters such as Alanine amino transferase (ALT), Aspartate amino transferase (AST), Alkaline phosphatase (ALP), Bilirubin, Total protein and Albumin in neonates from gestational diabetic pregnancy. Fifty women with GDM and fifty healthy pregnant women in their third trimester attending federal Teaching Hospital Ido-Ekiti were recruited into the study. Serum concentrations of ALT, AST, ALP, Bilirubin, Total protein and Albumin in the neonates were determined. Significant decrease (p<0.05) in the activity of ALT in the test group (4.4400±1.01546) when compared with the control group (7.9400±3.47637) was reported in this study while ALP activity in the test group (35.2000±4.15746) increased significantly when compared with the control group (31.0000±2.87131). However, no significant difference was observed in the activity of AST between the groups. The report shows significant decrease in concentration of direct bilirubin in the test group (0.2200±0.4163) when compared with that of the control group (0.2700±0.03350) while no significant difference in the total bilirubin concentration between the groups was reported in the study. No significant differences (p<0.05) in the concentrations of Total protein and Albumin between the groups were reported in this study. Fetuses of pregnancies complicated with GDM are at increased risks of neonatal adverse outcomes. This study revealed the clinical implications of GDM on liver functions of neonates from pregnancies complicated with GDM.

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