Abstract

ANTIPARKINSON’S STUDIES OF ETHANOLIC EXTRACT OF LEUCAS ASPERA IN MICE

Ramalingam Ramani*, Bindu Madhavi Boddupalli, Sujeevana Kandati, RavinderNath Anisetti, Nalgulu Malothu, Raja Rao Proddoku

ABSTRACT

Parkinson’s disorder is given prominent focus in the neurological disorder research as the estimated deaths are increasing in the near future. The present investigation was aimed at the effect of ethanolic extract of Leucas aspera on rotenone induced parkinson’s disorder in mice. Rotenone induced parkinson’s disorder in mice was selected as the experimental model. The behavior parameters like, general behavior, catalepsy, neuromuscular coordination along with the biochemical parameters like, malondialdehyde, glutothione and dopamine contents were estimated. The results indicate the protective effect of the extract against rotenone induced parkinson’s disorder in both the behavioral parameters and the biochemical parameters. The results were found to be significant. Oxidative stress in the brain can be one of the leading causes for Parkinson’s disorder. Flavonoids from natural source with their antioxidant capacity can be the suitable curing option for the disease.

Keywords: Catalepsy, Dopamine, Malondialdehyde, Oxidative stress, Rotenone.