Abstract

EVALUATION OF ANTIMICROBIAL ACTIVITY OF CU(II), NI(II), CO(II) AND MN(II) METAL CHELATES OF SCHIFF BASES

*S.Anbuselvi and V.Jayamani

ABSTRACT

The complexes of schiff base possess remarkable antibacterial property. Review of literature also indicate that the metal complexes are better antimicrobial agents as compared to free schiff bases. In the present work we discuss about the antibacterial activity of Cu(II), Ni(II), Co(II) and Mn(II) metal chelates of 4-methyl[(5ʹ-naphthylazo- 2ʹ-hydroxybenzylidene) amino] benzene and Cu(II), Ni(II), Co(II) and Mn(II) metal chelates of N,Nʹ-bis(2-hydroxybenzylidene)-1,2- diaminobenzene. The complexeshave been screened for their in vitro antibacterial activity against three bacteria, Lactobacillus, S.aureus and K.aerogenes. The Copper complexes were shown to possess more antibacterial activity than the other Schiff-base complexes.

Keywords: K.aerogenes., benzene, metal chelate.