Abstract

DEVELOPMENT OF POLYHERBAL ANTIMALARIAL FORMULATION

*Dhanalakshmi R, Roopa Karki, Mamatha GC, Divakar Goli

ABSTRACT

The objective of present study was to formulate and evaluate the polyherbal tablet formulation (PHF) for the treatment of malaria disease. Plants like Aegle marmelos L., sida acuta B., and Ocimum basilicum L. gives various pharmacological properties like anti– malarial, anti-oxidant, anti-diabetic and anti–inflammatory activities. Literature survey revealed that many phytoconstituents like flavonoids, saponins, alkaloids, tannins, glycosides were extracted from leaves of Aegle marmelos L.(Bael), Sida acuta B.(Common wireweed)., and Ocimum basilicum L.(Sweet basil). Preliminary phytochemical screening of the Methanolic extract of leaves of Bael, Ethanolic extract of leaves of common wireweed and sweet basil revealed the presence of alkaloids, carbohydrates, flavonoids. Saponins were absent in methanolic/ethanolic extracts except common wireweed. Glycosides were absent in methanolic/ethanolic extracts except sweet basil. TLC studies were carried out for extracts. In this study, the PHF contained three different drugs viz., Aegle marmelos L., Sida acuta B., and Ocimum basilicum L. in variable amount along with Starch/PVP as binder, MCC as disintegrant, dibasic calcium phosphate as diluent, PEG 4000 as a polymer and magnesium stearate (1%) as lubricant, methyl paraben (0.1%) as preservative by wet granulation method. Tablet properties of the formulation (F5) were found to be satisfactory and stable when tested for stability studies at 30 ± 2°C / 65 ± 5% RH.

Keywords: Anti-malarial; Polyherbal formulation (PHF); Aegle marmelos L.; sida acuta B.; and Ocimum basilicum L.