Abstract

EVALUATION OF ANTI ALZHEIMER’S ACTIVITY OF ETHANOLIC BARK EXTRACT OF Albizia lebbecck benth IN SPRAGUE-DAWLEY RATS

Ganesan Ariharasivakumar*, R.D. Winkodi, S. Ajay and G.C. Leela Priyanka

ABSTRACT

Introduction: Alzheimer‟s disease is a type of dementia. Impaired learning and loss of memory, loss of memory are most common cause for this disease. In the present study Alzheimer‟s disease was chemically induced using Lipopolysaccarides intra-peritoneal injections in rats. Albizia lebbeck benth (Mimosaceae) is a medicinal plant commonly fast growing deciduous tree. To evaluate anti Alzheimer‟s activity on Albizia lebbeck benth bark. Methods: The Anti Alzheimer‟s activity of ethanolic extract of Albizia lebbeck benth bark was tested by water maze, Ymaze and open field test in albino rats. The rats were divided into nine groups. The first group remains control, second group untreated group, third group given gut microbiota with donapezil, fourth group given GM with ALB low dose, fifth group given GM with ALB high dose, sixth group given donapezil with quercetin, seventh group given GM with ALB high dose and Donapezil, eight group given ALB high dose, nineth group given ALB low dose. Results: In this study we have compared the Donapezil untreated group, GM+donapezil, GM+ALB low dose, GM+ALB high dose, donapezil+quercetin, GM+ALB high dose+Donapezil, ALB high dose and ALB low dose with control and found significant increase, based on our results we can conclude that ALB, donapezil, quercetin and GM can reduce Alzheimer‟s. Conclusion: The ethanolic extract of bark of Albizia lebbeck benth has significant anti Alzheimer‟s activity in animal models for Alzheimer‟s.

Keywords: Albizia lebbeck benth, water maze, Y maze, open field test, Alzheimer?s, Anti Alzheimer?s, Lipopolysaccarides.