Abstract

EVALUATION OF POLYHERBAL FORMULATION FOR WOUND HEALING ACTIVITY USING EXCISION MODEL

Ashwini Singh*, N.P.S. Sengar

ABSTRACT

Wound can be described as a breach in the normal tissue continuum, which leads to mechanical separation of functional structures such as blood vessels, inflammation and at a later stage, infection. Wound healing is a complex multifactorial process that results in the contraction and closure of the wound and restoration of a functional barrier. Proper healing of wound is essential for the restoration of disrupted functional status of skin. It is a product of the integrated response of several cell types to injury. In the present study, polyherbal formulation of Hydroalcholic extracts of the leaves of Azadirchta indica ,Cassia fistula, Eucalyptus globulus and bulbs of Allium sativum was investigated for their wound healing activity. The wound healing property appears to be due to the presence of active principles, which accelerates the healing process and confers breaking strength to the healed wound. Further, wound healing activity by polyherbal formulation may be attributed to the synergistic action of the active phyto-constituents like like Flavonoid, Tannis and Steroids.

Keywords: Wound healing, Azadirchta indica, Cassia fistula, Eucalyptus globulus ,Allium sativum, Polyherbal formulation.