Abstract

SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL, ANTIFUNGAL, ANTIOXIDANT AND DNA INTERACTION STUDIES OF THIOSEMICARBAZONE TRANSITION METAL COMPLEXES

Richa Kothari*, Brajraj Sharma

ABSTRACT

Pd(II) complexes of the formula [M(L)2X2] where L = N, N, - bis p- Methoxy acetophenone were synthesized as microcrystalline powders and characterized by elemental analysis viz. conductivity, FTIR, 1HNMR, LC-MS data and electronic spectra. The synthesized compounds were screened for their invitro growth inhibiting activity against different strains of bacteria viz. Escherichia coli, Bacillus subtilis and S. aureus and fungal strains A. Niger and Candida albicans were compared with the standard antibiotic tetracycline and flucozole. Furthermore, the antioxidant activity of the ligand and its complexes were determined invitro by the nitric oxide scavenging method.

Keywords: Schiff base ligands, Transition metals, spectral studies, Antibacterial, Antioxidant activities.