Abstract

FORMULATION DEVELPOMENT AND CHARACTERIZATION OF BILASTINE ORODISPERSIBLE TABLETS USING DIFFERENT SUPERDISINTEGRANTS

Dr. A. Abdul Hasan Sathali* and P. Rahmath Nisha

ABSTRACT

Allergic diseases are perhaps one of the most common persistent diseases in modern society; as a result, patients' lives and quality of life are impaired, and their impact is both detrimental and far-reaching. Bilastine is an antiallergenic medication (H1 antihistamine) that is used to treat allergic rhinoconjunctivitis and urticaria. Bilastine has a 61% oral bioavailability and a biological half-life (12-14.5hours). In the treatment of allergies, the early commencement of action is a crucial problem. There is instability and inability to focus on work when patients have abrupt allergic reactions. In this work, an attempt was made to create orodispersible tablets of bilastine with the goal of achieving a faster start of action by improved disintegration and dissolve rates, hence increasing the drug's bioavailability. The tablets were prepared by direct compression method and the effects of different superdisintegrants (croscarmellose sodium, crospovidone, guar gum, plantago ovata husk) in three different concentrations are examined for selection of best superdisintegrant. The FT-IR Preformulation investigations found no interactions between the medication and the excipients. The precompression characteristics of the prepared formulations were characterized, and the values were within prescribed limits, indicating good flowing properties. The formulated tablets were characterized for wetting time, disintegration time, content homogeneity, and in-vitro dissolution. Amongst all formulations, F6, which contains 7.5 % crospovidone, was considered to be the best of all formulations since it demonstrated quick in-vitro disintegration time and drug release via dissolving.

Keywords: Bilastine, Orodispersible tablets, Superdisintegrants.