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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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Updated Version

WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS: MAY ISSUE PUBLISHED

May Issue has been successfully launched on 1 May 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

CONVERSION OF KETONES AND ALCOHOLS BY A MICROBIAL NADP-DEPENDENT ALCOHOL DEHYDROGENASE

Michele Vitolo*

ABSTRACT

Alcohol dehydrogenase from Thermoanaerobium brockii (ADH), depending on the pH of reaction medium, catalyzes the reduction of ketones to alcohols with the simultaneous consumption of NADPH and vice-versa. Ketone reduction and alcohol oxidation occur at acid and alkaline pH, respectively. The capability of ADH to catalyze both ketone reduction and alcohol oxidation under different reaction conditions opens the possibility to develop processes in a membrane bioreactor operated in continuous mode to produce chiral alcohols from prochiral ketones. Preliminary data has shown that 1-
phenylethanol and 2-hexanol can be synthesized from acetophenone and 2-hexanone, respectively, since NADPH regeneration during the process was ensured.

Keywords: Alcohol dehydrogenase, NADP, NADPH, Ketones, Alcohols.

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