Abstract

A METFORMIN- GLICLAZIDE MULTIDRUG CRYSTAL SYNTHESIS, CRYSTAL STRUCTURE ANALYSIS AND BIOLOGICAL ANALYSIS

Nivash M., Dheenadhayalan K.*, Surya S., Shrihari E., Merin Job, Shibla Nasreen C., Dharuman J. and Jeevanandham S.

ABSTRACT

A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method and condensation method. This multi component crystal consisted of antidiabetic drugs Gliclazide (Gli) and Metformin (Met), which was performed by FTIR and single crystal X-ray structure analysis. The results showed an some changes in combination of Met and Gli and new molecules on produced by condensation method. The molecule shows anti diabetic activity.

Keywords: Gliclazide, Metformin, Solvent evaporation, Condensation.