Abstract

FORMULATION AND EVALUATION OF LIPOSOMAL DRUG DELIVERY SYSTEM FOR FENOPROFEN

Dhiraj Arvind Vaitage*, Brajesh Kumar Arjariya, Ravi Prakash, Praveen Jain and Sheenam Mansuri

ABSTRACT

The main objective of this work was designed to prepare and evaluate the Fenoprofen Liposomes. This formulation will target the site of action with effect of various stabilizers on drug entrapment efficiency, and to reduce the side effects by formulating non-pegylated Liposomes. The Liposomes were prepared by dried thin film hydration technique using a rotary evaporator with drug, carrier, ammonium sulphate and stabilizers. The parameters like temperature, vacuum and RPM were maintained accordingly. After preparation, the Liposomes were stored in freeze condition, and given for further evaluation. All formulations follow Case II transport when it applied to the Korsmeyer– Peppas model for mechanism of drug release. F6 (negative) formulation has better kinetic results when compared to F2 and F4 formulations. The stability of the Fenoprofen Liposomes was evaluated after being stored at 40C and room temperature for 60 days. The assay of the samples was determined as a function of the storage at different time intervals. The Liposomes stored at 4oc were found to be stable for duration of three months from the results of physical characterization.

Keywords: Fenoprofen Liposomes, Stability, Formulation, Evaluation.