Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF PEDIATRIC ORAL MEDICATED JELLY OF PARACETAMOL AND IBUPROFEN

Shekhar Priyanshu*, Joshi Ankur, Malviya Sapna and Kharia Anil

ABSTRACT

The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Paracetamol and Ibuprofen for the treatment of mild to moderate pain. Ibuprofen + Paracetamol is used for pain relief and fever. It relieves pain in condition like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, period pain osteoarthritis or painful menses. Jellies are prepared by heating and congealing methods by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. All batches (F1-F2) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. The viscosity range was found to be 53305 to 61731cps. The drug content of Paracetamol of F1 & F2 96.06% and 98.15% and drug content of Ibuprofen of F1 & F2 was found 96.1% and 95.7%.

Keywords: Medicated Jelly, Paracetamol, Ibuprofen.