Abstract

EFFECT OF FK 506 ON RAT TISSUES OF ENZYMATIC LEVELS INVOLVED IN ENERGY METABOLISM

Chittibabu. B* and Ayya Raju. M

ABSTRACT

Immunosuppressive agent like FK 506 no doubt, impairs not only the cellular / tissue normal metabolic functions but certainly will alter the usual functions of cytochrome-P-450-mediated events and identical reasons may be responsible for FK 506 impaired ATP ases in the current study. From the current study, it is evident that FK 506 at a dose of 1 mg / kg over 7 or 28 days period impairs the rat tissue energy metabolism as evidenced by depleted levels of rat tissue ATPase and cytochrome-c-oxidase activities, since these enzymes are well known key enzymes necessary for maintenance of tissue energy metabolism.

Keywords: Albino rat, FK 506, ATPase, Cytochrome-c-oxidase.