Abstract

FORMULATION AND CHARACTERIZATION OF CAP-IN-CAP TECHNOLOGY FOR BIPHASIC DELIVERY 0F LORNOXICAM

Shalaka V. Borse* and Shweta R. Yadav

ABSTRACT

In the present research work, the study of new technology capsule-in-a-capsule for biphasic delivery of lornoxicam was done. In this technology the advantages of fast releasing liquid-filled-capsules and slow release beads-filled-capsules were combined to achieve the optimum biphasic delivery of drug. Lornoxicam slow releasing beads were prepared by ionotrophic gelation method by using hydrophilic polymer and were filled into a smaller capsule. Lornoxicam fast releasing liquid dispersion was prepared by using PVP K-30 as a solubility enhancer and further dissolving in PEG 400. This fast releasing liquid and slow releasing beads-filled-capsule are then inserted into a bigger capsule body and closed with the cap by sealing. The various formulation batches were subjected to physicochemical studies, entrapment efficiency, drug content, in vitro drug release and stability studies. The polymer-Drug interaction studies reveal that there was no interaction between drug and polymers employed in this study. The optimized capsule-in-a-capsule formulation released 29.61±0.27% at the end of 30 min and 96.56±075% of drug at the end of 12h. The stability results indicate that the various parameters of our optimized formulation are not affected on storage at 45°C/75%RH up to 2 months.

Keywords: Biphasic drug delivery system, Lornoxicam, Capsule-in-Capsule formulation, Slow release beads-filled-capsules, fast releasing liquid-filled-capsules.