Abstract

SYNTHESIS OF SOLID LIPID NANOPARTICLES USING DOUBLE EMULSION- SOLVENT EVAPORATION METHOD FOR RITONAVIR LOADED DRUG DELIVERY SYSTEM

Prerana Husukale* and Nikita Gurav

ABSTRACT

A large number of techniques like physical, mechanical, chemical and hybrid are available to synthesize different types of nanomaterial. Solid lipid nanoparticles (SLN) are sub- micron colloidal carriers ranging from 50 to 1000 nm introduced in 1991. SLNs are generally composed of biodegradable and biocompatible solid lipid as solid core, coated by nonhazardous surfactants/ co- surfactant as the outer shell. This is used for the controlled and targeted delivery of drugs & for incorporation of hydrophilic and lipophilic. Protease inhibitors used in the AIDS found to influence the glycoprotein synthesis independently which in turn inhibits the growth of HIV, one of the potential protease inhibitor could also acts as a substrate for efflux pump that is ultimately preventing its solubility in the gastric fluid by preparation of solid dispersion.

Keywords: Nanotechnology, Double emulsion method, Solid lipid nanoparticles (SLN), Ritonavir, Poloxamer.