SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL INDOLE DERIVATIVE
Shalini* and Sujeet Kumar Gupta
ABSTRACT
A novel generation of different Schiff base indole derivatives is reported which are evaluated for their anti-inflammatory. In the research different schiff base containing indole derivatives are synthesized through vilsmeier-haack reaction and further reaction with different substituted amines. The synthesized series have been confirmed on the basis of IR,1H-NMR and Mass spectroscopy and evaluated for their for their anti-inflammatory activities by using carrageenan induced rat paw edema model. The result shows that percentage inhibition of synthesized compound 4f was found to be highest against all the synthesized compounds where as diclofenac was taken as standard.
Keywords: Indole, Schiff base, vilsmeier-haack reaction, anti-inflammatory.
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