Abstract

NANOTECHNOLOGY BASED SI RNA’S THEARPY

*Rawat Swati¹, Malviya Sapna²

¹SND College of Pharmacy, Yeola, Nashik (M.S) - 423401
²Modern College of Pharmacy, Indore (M.P.), 452001

ABSTRACT

Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry. Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale (a nanometer is one billionth of a meter). Nanobiotechnology, an integration of physical sciences, molecular engineering, biology, chemistry and biotechnology holds considerable promise of advances in pharmaceuticals and healthcare. Benefits of nanotechnology, though limited, have driven efforts to develop advanced nanoparticles. This is particularly the case for targeted nucleic acid (gene) therapeutics based on short interfering ribonucleic acid (siRNA), which is a new gene inhibitor that is highly potent and selective that is relevant to nanobiotechnology. Need of an hour is to develop an innovative medicine i.e. (Nanomedicine) because of their impact on health care and regulation. One of the ‘revolutionary’ properties of siRNA is its potency, stability, and low level of nonspecific activity when synthesized without chemically stabilized RNA. This is an argument for focusing efforts to deliver siRNA as a therapeutic modality not by medicinal chemistry but by packaging.

Keywords: siRNA- short interfering ribonucleic acid, nanometer- one billionth of a meter.