Abstract

A REVIEW OF METHOD DEVELOPMENT FOR THE DETERMINATION AND ESTIMATION OF MEMANTINE-HCL BY USING DIFFERENT ANALYTICAL METHODS

Gajjelli Sushma* and Sreelatha Gangu

ABSTRACT

Memantine is a relatively new drug specially developed for use in moderate-to-severe dementia. It is an uncompetitive N-methyl-D-aspartate receptor antagonist and reduces glutamatergic excitotoxicity. Though Alzheimer’s disease (AD) is the commonest cause of dementia in the world, there is no “cure” available for the same. Cholinesterase inhibitors such as donepezil and rivastigmine have been shown to provide symptomatic relief in patients with AD but have no effect on disease progression or survival. Moreover, they are not helpful in more severe stages of dementia. Memantine has been shown to cause modest improvement in clinical symptoms in severe stages of AD and may retard the disease progression. Moreover, it has been shown to be useful in various forms of dementia including AD, vascular dementia and Wernicke-Korsakoff psychosis. It is also the first drug to cause complete disappearance of pendular nystagmus due to multiple sclerosis. The current review focuses on the pharmacological properties of Memantine and examines the recent evidence in favor of Memantine. Memantine is an uncompetitive N-methyl-D-aspartate receptor antagonist with moderate affinity. Its mechanism of action is neuroprotective and potentially therapeutic in several neuropsychiatric diseases. It has been approved by the FDA for the treatment of moderate to severe Alzheimer’s disease (AD) either as a monotherapy or in combination with cholinesterase inhibitors. This review covers key studies of Memantine’s safety and efficacy in treating moderate to severe AD. It also covers current research into other dementias including but not exclusively mild AD and vascular dementia. Other studies on the efficacy of Memantine for other neuropsychiatric diseases are discussed. Memantine is a safe and effective drug that merits further research on several topics. Clinicians should be aware of new studies and potential uses of Memantine because of its safety and efficacy.some analytical methods for the determination of Memantine HCL in pharmaceutical formulations like HPLC, LC-MS/MS, Chromatographic techniques, Spectroscopic methods developed in the estimation of MEMANTINE HCL was discovered in the present study.

Keywords: Alzheimer’s disease, Dementia, Memantine-HCL, HPLC, LC-MS/MS, Chromatographic techniques, Spectroscopic methods.