Abstract

A REVIEW ON NON AQUEOUS NANO EMULSION

Bade Gautam Adinath* and Ingale Divya Anil

ABSTRACT

Generally emulsions are water-in-oil or oil-inwater type, but emulsions may contain polar liquid as one of the phase. Non-aqueous nano-emulsions are useful in many situations where presence of water is not desirable, and formulation of active ingredients which undergo hydrolysis or oxidation in the presence of water. The non-aqueous nano emulsion subject to design a stable non-aqueous nanoemulsion (NANE) using cosmetically approved ingredients as a vehicle for the water-sensitive active ingredients. Non-aqueous nanoemulsion subject to increase the dermal penetration and permeation and study solubility and dermal bioavailability of drug. For better compliance, the nonaqueous nano emulsions will be incorporated in cosmetics or personal care products. A nonaqueous system was obtained with glycerin and olive oil stabilized by glycerol monosterate with co-surfactant. It was observed that emulsification behavior is completely unpredictable and conventional theories of emulsification and HLB system cannot be applied here. An optimized nonaqueous nano-emulsion is obtained through implementation of pseudoternary phase curve. Nonaqueous nano-emulsion region is determined and further characterized for pH, rheology, globule size analysis, zeta potential and stability. Stability studies (agitation, centrifugation, freeze thaw cycle, accelerated stability) were carried out at 5, 25 and 40 degree C. Results proved that nonaqueous nano-emulsion can be used as vehicle for the poorly watersoluble drug, suspension vehicles and oleogels. Non-aqueous nano-emulsion dosage forms have nano-sized droplets of disperse phase and are kinetically stable dosage form. Non-aqueous nanoemulsions are included under the category of new drug delivery system containing emulsified water in oil/oil in water system having mean globule size ranges from 10 nm to 1000 nm.

Keywords: Non-aqueous nano emulsion, HLB, Pseudo-ternary phase curve, Zeta Potential.