Abstract

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION AND ESTIMATION OF METFORMIN HYDROCHLORIDE BY USING DIFFERENT ANALYTICAL METHODS

Mani Kameshwari D., Ajitha A.* and Dr. Rama Rao

ABSTRACT

Metformin hydrochloride which is chemically known as dimethylbiguanide is an anti hyperglycaemic drug used for the management and treatment of noninsulin dependent diabetes especially diabetes mellitus.. Metformin, sold under the brand name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. It is not associated with weight gain and is taken by mouth. It is sometimes used as an off-label augment to attenuate the risk of weight gain in people who take antipsychotics as well as phenelzine Metformin can be analysed by various analytical methods. Mostly HPLC method is widely used. Other than HPTLC, UV spectroscopy, TLC, potentiometry are also used for estimation and analysis. The following review describes about the various methods that are used to estimate the metformin hydrochloride

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