Abstract

OMICRON SARS COV 2 VARIANT OF CONCERN A GLOBAL FOCUS: EVOLUTION, MUTATION, AND EFFECT OF THE VACCINE

Dr. Deepthi G N* and G K Lakshmi Manasa

ABSTRACT

WHO discovered a mutant of covid 19 variant termed as SARS COV 2 and identified it as a variant of concern (VOC). We can extrapolate to produce conclusive proof based on omicron mutations to furnish preliminary evidence of transmissibility and virulence As of December 16, 2021. These SARS COV 2 vaccines appeared to be highly effective in clinical studies eliciting neutralizing humoral and cellular immunity as well as reducing covid 19 infection hospitalization and death. The omicron exhibits large divergence and illustrates mutations in spike glycoprotein thus emerging with 15 RBD mutations and has been identified in 89 countries. The spike mutation is predicted to have an overwhelmingly disruptive effect, making omicron more likely to have vaccine breakthroughs. The SARS-CoV-2 spike protein must be cleaved twice by host proteases that hydrolyze peptide bonds at certain amino acid sequences to gain cellular entrance. The omicron variant exhibits divergence due to mutations observed in spike glycoprotein. The omicron variant exhibits significant transmissibility and infectivity as a result of this mutation in the S protein. The administration of a booster vaccine that targets the spike protein will allow memory B cells to produce neutralizing antibodies.

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