Abstract

A REVIEW: SIMULTANEOUS EQUATION METHODS FOR THE ESTIMATION OF EBASTINE AND PHENYLEPHRINE HYDROCHLORIDE IN COMBINED TABLET DOSAGE FORM

Rahul Jadhav*, Dr. Sanjay B. Bhawar and Mayur S. Bhosale

ABSTRACT

New, easy, accurate and sensitive UV-spectrophotometric absorption adjustment simultaneous mathematical method and method are simultaneously designed Ebastine and Phenylephrine HCL dosage for bulk and dosage of combined tabletform. Methanol was used as a solvent. The wavelength selected for the absorption adjustment The route was 225 nm and 253 nm for Ebastine and Phenylephrine HCL respectively and for The case for the simultaneous mathematical model was 240 nm and 275 nm of Ebastine and Phenylephrine HCL respectively. The law of beer obeyed the mid range 4 - 40 μg / ml, in both drugs. Percentage of acquisition is obtained in the range of 100.42 - 101.27% Ebastine and 100.51 - 101.40% Phenylephrine HCL. Improved methods were validated statistically and by recovery studies. % RSD value found be less than 2. So the proposed methods are simple, accurate, economical, and fast accurate and can be used effectively in the simultaneous determination of Ebastine as well Phenylephrine HCL in bulk and in the form of an integrated tablet.

Keywords: Ebastine, Phenylephrine HCL, Simultaneous equation method.