Abstract

COLON DRUG DELIVERY SYSTEM: A RECENT CONVENTIONAL AND NOVEL APPROACH

Ripal Mistry*

ABSTRACT

Colon-targeted delivery of drugs has recently gained importance in addressing specific needs in the therapy of colon based diseases. Many techniques have been tried for the development of colon targeted drug delivery systems. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review, mainly compares the primary approaches for CDDS (Colon Specific Drug Delivery) namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and had limitations as compared with newer CDDS namely pressure controlled colonic delivery capsules, CODESTM, and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of manufacturing process.

Keywords: Colon specific drug delivery, Microbial Flora, pH sensitivity, Pressure-controlled, Microparticulate systems.