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Abstract

EFFECT OF VARIOUS MEMBRANES AND THEIR THICKNESS ON OSMOTIC TABLET OF ETEROCOXIB

*Sameer Sheaikh1, A.V. Chandewar2

1Prist University, Vallam, Thanjavur- 613403 (T.N.)
2P. Wadhwani college of pharmacy,Yavatmal – 445001 (M. S.), India.

ABSTRACT

Osmotic tablet of Eterocoxib is prepared successfully to deliver drug in controlled release form for once day therapy in arthritis by overcoming all the sideeffect and enhancing bioavailability. Osmotic systems use the principle of osmosis as delivery force to deliver the drug from the system, and the release rate is unaffected by the body’s pH and other physiological and gastrointestinal factors. The objective of the present work was to design osmotically driven oral drug delivery system containing Eterocoxib as an active ingredient and evaluate the effect of various membranes( microporous and semipermiable) on release of drug from osmotic tablet. Core tablet of Eterocoxib is prepared, coated with cellulose acetate (39.8 D.S.) in which batch 6b (semipermiable) give the maximum of 65.09% release (zero order) from osmotic tablet of Eterocoxib in control passion as compare to other(microporous) membrane coated batches which give first order release.

Keywords: Eterocoxib, NSAID’s, oral osmotic tablet, cellulose acetat, Osmotic tablet.


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