Abstract

REVIEW ON ANALYTICAL METHOD DEVELOPMENT FOR ESTIMATION OF DEFERIPRONE FROM THE BULK DOSAGE FORM

Shweta Ubale*, Mayur Bhosale, Dr. S. K. Parajne and H.S. Bhawar

ABSTRACT

Deferiprone is chemically 3-hydroxy-1,2-dimethyl pyridine-4-one[1,5] it is an oral iron-chelating agent used to treat transfusion-related, chronic iron overload. Deferiprone has been linked to a low rate of Transitory serum aminotransferase elevations during treatment and too rare cases of clinically apparent liver injury. It is an orally bioavailable bidentate ligand with iron-chelating activity. Deferiprone binds to iron in a 3:1 (ligand: iron) molecular ratio. By binding to iron, it can remove excess iron from the body. Deferiprone is a member of the class of 4- pyridones that is pyridine-4(1H)-one substituted at positions 1 and 2 by methyl groups and position 3 by a hydroxy group. A lipid-soluble ironchelator used for the treatment of thalassemia. It has a role as a protective agent and iron chelator. Some analytical methods of quantitative determination of Deferiprone in a pharmaceutical formulation like UV, RP-HPLC, LC-MS/MS, HPLC MS/MS, UFLC.

Keywords: Deferiprone, thalassemia major, UV, RP-HPLC.