Abstract

DESIGN, SYNTHESIS, ANTIMICROBIAL, AND ANTIINFLAMMATORY ACTIVITY OF NOVEL ISOXAZOLYL PYRROLO[2,3-d]PYRIMIDINES

Nagi Reddy Modugu*,Rajanarendar Eligeti, Reddy Y N

ABSTRACT

Novel series of isoxazolyl pyrrolo[2,3-d]pyrimidines 11 have been synthesized from 4-amino-3-methyl-5-styrylisoxazole 7. Compound 7 on treatment with phenacyl bromide 8 afforded the corresponding phenacyl isoxazolylamines 9, which were condensed with malononitrile to afford compounds 10. Compounds 10, were reacted with thiourea in refluxing ethanol to give the title compounds 11. Compounds 9-11 were characterized by IR, 1H NMR, 13C NMR and Mass spectral data. The title compounds 11a-g were evaluated for their antimicrobial, and anti-inflammatory activity. Compounds 11f and 11g exhibited significant antimicrobial activity and potent antiinflammatory activities as that of standard drugs.

Keywords: isoxazolyl pyrrolo[2,3-d]pyrimidines, Antimicrobial activity, Anti-inflammatory activity.