Abstract

AREVIEW ON FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF VILAZODONE SOLID DISPERSIONS

Perumala Harish Kumar*, M.V. Jhansi Priya and Narapusetty Naidu

ABSTRACT

The main aim of present work is to formulate solid dispersions of poorly water soluble BCS class 2 drug Vilazodone, which give the application of solid dispersions results in increasing the solubility of many poorly soluble drugs the objective of the present study, investigated to improve the solubility of and Vilazodone by using HP β Cyclodextrin and β Cyclodextrin to improve patient compliance. A solid dispersion technique has been used by various researchers who have reported encouraging results with different drugs the first drug whose rate and extent of absorption was significantly enhanced using the solid dispersion technique was sulfathiazole by Sekiguchi and Obi (Sekiguchi, 1961). Technique for the preparation of solid dispersions, Lyophilization has also been thought of as a molecular mixing technique where the drug and carrier were co-dissolved in cyclohexanol, frozen and then sublimed under vacuum to obtain a lyophilized molecular dispersion (Lin, 1980). Numerous solid dispersion systems have been demonstrated in the pharmaceutical literature to improve the dissolution properties of poorly water-soluble drugs. Other methods, such as salt formation, complexation with cyclodextrins, solubilization of drugs in solvent(s), and particle size reduction have also been utilized to improve the dissolution properties of poorly water-soluble drugs; however, there are substantial limitations with each of these techniques. On the other hand, formulation of drugs as solid dispersions offers a variety of processing and excipient options that allow for flexibility when formulating oral delivery systems for poorly water-soluble drugs.

Keywords: cyclohexanol (1) Lyophilization (2) sulfathiazole (3)