Abstract

AMLODIPINE AFFECT THE BLOOD PRESSURE IN RENAL DISFUNCTION OF HYPERTENSION RATS

Ayu Trianingsih*, Almahdy A. and Yufri Aldi

ABSTRACT

Research on the effect of amlodipine in lowering blood pressure in hypertensive male white rats with renal dysfunction of male white rats has been done. In this study, amlodipine was used with varying doses of 5 mg, 10 mg, and 20 mg with variations in the timing of blood pressure measurements at hour 1, hour 2, an hour 3. The parameters observed were systolic and diastolic blood pressure. Two-way ANOVA was used to examine the data in this study. The results showed that complication of kidney disfunction had a substantial influence on lowering systolic and diastolic blood pressure in hypertensive rats (p<0.05). Amlodipin at doses of 5 mg, 10 mg, and 20 mg significantly reduced systolic and diastolic blood pressure (p<0.05). From the results of the research data, it can be seen that the presence of complications in hypertension such as hypertension-kidney dysfunction affects the decrease in blood pressure of rats. In which rats with complications of kidney dysfunction decreased blood pressure smaller than hypertensive rats without complications.

Keywords: Amlodipine, Hypertension, Sistole, Diastole, Renal dysfunction.