Abstract

SYNTHESIS, BIOLOGICAL & PHARMACOLOGICAL SCREENING OF 8-FLUORO-9-SUBSTITUTED (1,3) BENZOTHIAZOLE(51-b) 3-SUBSTITUTED 1,2,4 TRIAZOLE

Priyanka K. Patil*, E Jayachandran, Shivaraj D. Sadekar, Basavaraj K. Nanjwade, Farag Younes Muhamed and Janar Jenis

ABSTRACT

In this studies fluorochloroaniline were treated with Potassium Thiocyanate (KSCN) in the presence of bromine in glacial acetic acid and ammonia to get 2- amino–6-fluoro-7-chloro (1,3)- benzothiozole, which was treated with hydrazine hydrate and ethylene glycol in presence of conc. HCl and reflux for 8 hrs, to get 7- chloro- 6- fluoro-2-hydrazinyl- 1, 3- benzothiazole. Which is further treated with ethyl aceto acetate and refluxed using ethanol as solvent to get 8-chloro-7-fluoro-1-[4-methylphenyl] sulphonyl-1,9a-dihydro [1,2,4] triazolo[3,4-b] [1,3] benzothiazole To the above product different aromatic amines, as well as various primary and secondary amines in presence of DMF were treated to get newly targeted compounds by replacing chlorine at 7th position. The synthesized compounds were characterised by solubility, TLC, analytical data, UV-visible, IR, 1HNMR and Mass spectral studies, then compounds were screened for anti-bacterial, anti-fungal and anti-inflammatory (in-vitro), activities.

Keywords: Benzothizole, triazole, benzothiozole, fluorochloroaniline, potassium thiocyanate.