Abstract

EVOLUTION OF ANTI-INFLAMMATORY ACTIVITY ON CURCUMA LONGA (RHIZOME) AND BRYOPHYLLUM PINNATUM (LEAVES)

Jyotsana Patidar*, Asha Rani Pyati, Jaya Sharma, P. K. Dubey and
Rajendra Bapna

ABSTRACT

Introduction: Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals or microbiological agents. It is a complex reaction usually necrotic, cells that consist of vascular response, migration and activation of leucocytes and systemic reaction. Anti-inflammatory agents are use in the treatment of inflammation. Bryophyllum Pinnatum and Curcuma Longa is emerging plant of interest of multipurpose use. Evaluate the anti-inflammatory activity of herbal formulation containing two different extracts of Bryophyllum Pinnatum and Curcuma Longa in different proportions (1:2 and 2:1) respectively. Methods: Dried Bryophyllum Pinnatum and Curcuma Longa extracted with methanol by using soxhlet apparatus. Carrageenan inflammation was used to evaluate anti- inflammatory activities of extract in wistar rat. Each experiment consisted of 24 animals randomly but equally divided into groups. Group A was taken as control and the Group B was treated with the standard drug Indomethacin (10 mg/kg). The methanol extract of herbal formulation of Bryophyllum Pinnatum and Curcuma longa 600 mg/kg Group C and D in the proportion of 1:2 and 2:1. Results: The herbal formulation has significantly decrease the development of paw edema induced by Carrageenan in rats as compared to the control and standard drug group. The Phytochemical screening of the methanolic extract of Bryophyllum Pinnatum and curcuma longa revealed the presence of flavanoid, tannins, saponins, triterpenes, cardiac glycosides, steroids, phenols and alkaloids.

Keywords: Anti-inflammatory, Bryophyllum Pinnatum, Curcuma longa, Carrageenan, Indomethacin.