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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2020 Issue has been successfully launched on 1 September 2020.

Abstract

SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF THIAZOLIDINE-4-ONE DERIVATIVE

*S.Ramachandran, S.Abdul Rahman, Jiwan Kumar Basnet, M.Kamarudeen, S.A.Shahina, P.Shanmugapandiyan

Department of Pharmaceutical Chemistry, Mohamed Sathak .A.J. College of Pharmacy, Shollinganallur, Chennai 600119, (INDIA).

ABSTRACT

A new series of 2-phenyl-3-(pyridin-yl)-thiazolidine-4-one derivatives were synthesized by the reaction of schiff base (2-aminopyridine and 4-dimethyl amino benzaldehyde) with mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. . The synthesized compounds showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords: Antibacterial, Aromatic aldehyde, Pyridine, Schiff Bases, Thiazolidine-4-one.


[Full Text Article]

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