Abstract

ASSESSMENT OF ANTIOXIDANT AND ANTIARTHRITIC ACTIVITY OF MENTHA SUBSESSILIS IN ALBINO WISTAR RATS

Nukala Charan Sai*, P. Dharani Prasad and C. Bhuvaneswara Rao

ABSTRACT

To evaluate the antioxidant and antiarthritic activity of ethanolic extract of leaves of Mentha subsessilis (Lamiaceae) EEMS in alloxan induced diabetic rats. The (EEMS) have been proven experimentally to possess antioxidant activity in invitro methods. EEMS showed effective response DPPH method for determining IC50 were recorded as 5.12μg/ml and for 6.13μg/ml for EEMS and standard ascorbic acid. The ethanolic extract of Mentha subsessilis and at the dose of 400mg/kg had shown the suppression of inflammatory substances and free radicals, in Carrageenan induced paw oedema and Cotton pellet method. The plant extracts of 200mg/kg and 400mg/kg of EEMS decreased the paw volume from day 14th, the plant extracts 400mg/kg of EEMS had shown decrease in knee diameter from 14th day, the results revealed that the extract at the dose of 400mg/kg of EEMS had shown 35.96% inhibition in weight of dry cotton pellets, Therefore the decrease in granuloma weight indicates suppression of the proliferative phases, which was effectively inhibited by extracts of EEMS. The results of biochemical and histopathological studies suggest that, EEMS possesses significant anti arthritic property and antioxidant activity compared to ascorbic acid.

Keywords: Mentha subsessilis, Antioxidants, Anti arthritic, Carrageenan, Cotton pellet etc.