Abstract

A REVIEW ON NOVEL VESICULAR DRUG DELIVERY: KETOCONAZOLE

Priyanka Tiwari* and Anjali Kushwaha

ABSTRACT

This study was to investigate the feasibility of using niosome as a transdermal drug delivery system for ketoconazole. Topically applied noisome can increase residence time of drug in the stratum corneum and epidermis, while reducing the systemic absorption of the drug. It also improves the horny layer properties both by reducing transepidermal water loss and by increasing smoothness via replenishing lost skin lipids. Niosomes play an increasingly important role in drug delivery as they can reduce toxicity and modify pharmacokinetic and bio-availability. Topically applied niosomes can increase the residence time of drugs in the stratum corneum and epidermis, while reducing the systemic absorption of the drug. It can act as drug containing reservoirs and the modification of the vesicular compositions or surface properties can adjust the drug release rate and the affinity for the target site. Ketoconazole is a broad spectrum Imidazole derivative useful in the treatment of superficial and systemic fungal infections.

Keywords: Niosome, ketoconazole, transdermal, stratum corneum, epidermis.