Abstract

ANALYTICAL TECHNIQUES FOR THE DRUGS USED IN ALOPECIA AREATA – A REVIEW

Asha Deepti* and Baikadi Mamatha

ABSTRACT

Alopecia areata (AA) is non-scarring alopecia that affects 0.1-0.2 per cent of the population and causes well-defined areas of fast hair loss. The cause of AA is thought to be both genetic and autoimmune. There are 139 single nucleotide polymorphisms connected to AA in 8 regions of the genome, all of which are linked to T cells or the hair follicle. Furthermore, patients with AA have a higher incidence of autoantibodies specific to hair follicles. Alopecia areata is an autoimmune condition marked by non-scarring hair loss and hair follicle preservation. Hair loss can take many forms, from well-defined patches to diffuse or complete hair loss that affects all hair-bearing sites. Patchy alopecia areata, which affects the scalp, is the most common type. Alopecia areata affects around 2% of the general population at some point in their lives. Skin biopsies demonstrate a lymphocytic infiltrate in and around the bulb or bottom portion of the hair follicle during the anagen (hair growth) phase. Clobetasol Propionate, Tianeptine, Valproic acid, Quercetin, and Simvastatin are some medications utilised in the treatment. The present study is a brief review of the analytical methods developed for estimation of these drugs.

Keywords: Alopecia areata, Clobetasol propionate, Tianeptine, Valproic acid, Quercetin, Simvastatin, Analytical methods.