Abstract

A REVIEW ON CURCUMIN: THE SOLID GOLD HERBAL MEDICATION

A. K. Ramya, Ajit Kumar Varma, Ayushmaan Roy, Pooja Negi, Deepadarshan Urs, Anurag Chourasia*

ABSTRACT

Curcumin, a polyphenol found in turmeric, has attracted attention from both the medical and culinary worlds because it is the primary source of the spice's medicinal qualities. Oxidative and inflammatory diseases, metabolic syndrome, arthritis, anxiety, and hyperlipidemia can all be managed with this supplement. As a result, active persons may benefit from the supplement's ability to reduce inflammation and muscular soreness following exercise. For those who have not been diagnosed with a medical ailment, even a little dose of the complex can have health benefits. Its antioxidant and anti-inflammatory properties are responsible for most of these advantages. Curcumin's poor bioavailability, which appears to be mostly attributable to poor absorption, fast metabolism, and rapid elimination, does not contribute to the related health benefits. Bioavailability can be improved by a variety of factors. Curcumin (diferuloylmethane) is one of turmeric's most potent, non-toxic, and major bioactive ingredients. Curcumin has a weak bioavailability and low absorption rate. Curcumin nanoparticles can be used to treat cancer and wound infections, according to the findings of this study. Antibacterial, antiviral, and antiprotozoan properties of curcumin nanoparticles are excellent. As a result of this, curcumin-loaded nanoparticles can be used for drug administration in nano-gel, microemulsion, and nano-cream forms of the nanoparticle. An important component of turmeric known as curcumin is the curcuma longa linn rhizome. Since its discovery in the 16th century, curcumin has been used to treat a wide range of ailments. Curcumin's anti-oxidant and anti-inflammatory properties play a significant role in a wide range of maladies, including cancer, cardiovascular disease, Alzheimer's disease, inflammatory disorders, neurological diseases, and so on. Although natural curcumin has made amazing achievements in therapeutic applications, the clinical implications of native curcumin are hindered by restricted solubility, chemical-physical instability, poor bioavailability, rapid metabolism and poor phartacokinetics. There are several intriguing biological effects of curcumin that have been summarised here.

Keywords: Curcumin, Curcuma longa, Anticancer, Curcuminoids, Turmeric.