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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

EVALUATION OF ANTICONVULSANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF MIMOSA PUDICA THORNS ON LABORATORY ANIMALS

GB Alaka Kar*, Susanta Kumar Rout and Debashisa Mishra

ABSTRACT

Objective: To investigate the anticonvulsant activity of hydroalcoholic extracts of leaves and roots of Mimosa Pudica Thorns and its fractions (Chloroform, ethyl acetate, methanol and aqueous) against pentylenetetrazole (PTZ), maximal electroshock (MES), Strychnine (STR), convulsions at different dose levels. Methods: The anticonvulsant effect of MES, PTZ, and STR induced seizure. Results: The extract at 200 and 400 mg/ kg, produced a significant (P<0.01) dose dependent increase in onset of convulsion compared to the control in MES, PTZ and strychnine - induced seizures. Conclustions: The data obtained indicates that Hydroalcoholic extracts of Mimosa Pudica leaves and roots may help to control grandmal and petitmal epilepsy.

Keywords: Epilepsy, Mimosa pudica root extract, MES, PTZ model.

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