Abstract

FORMULATION AND EVALUATION STUDIES OF ORALLY DISINTEGRATING TABLETS OF FUROSEMIDE BY DIRECT COMPRESSION USING LIQUISOLID COMPACT TECHNIQUE

Prashant Kumar*, Anuj Mittal and MS. Anuj Pradhania

ABSTRACT

The main objective of this study is to formulate an orodispersible tablets of furosemide by liquisolid technique using various super disintegrants to increase the disintegration of the furosemide tablets which leads to faster dissolution and ultimately enhanced bioavailability of furosemide. Methods:- Liquisolid compacts of the furosemide were prepared by using various excipients like microcrystalline cellulose (Avicel PH-102) as a carrier, colloidal silicon dioxide (Aerosil 200) as a coating material, sodium starch glycolate (SSG) as a disintegrants, and propylene glycol as liquid vehicle. These prepared liquisolid compacts are then converted into ODTs by direct compression method using three different Superdisintegrants i.e. croscarmellose sodium (CSS), sodium starch glycolate (SSG), and crospovidone (CP) with other excipients. Results:- Results obtained from different studies showed that the liquisolid ODTs were found to be within the acceptable limits of different parameters. Among the three super disintegrants, SSG found to be the best in term of showing the best drug release profile as compared to the other two superdisintegrants. The optimized selected formula (F-IV) was prepared using 8mg SSG, by direct compression showed the maximum drug release profile with 98.74% drug release at 25 min. Additionally, the selected formula had an acceptable hardness and friability, so it was selected as the best formula. Conclusion:- The overall results showed that the formulation F-I and F-IV containing Sodium starch glycolate as superdisintegrant along with microcrystalline cellulose as diluent was found to be better one compared to the other formulations and satisfied criteria for orally disintegrating tablets.

Keywords: Furosemide, Orodispersible tablet, Liquisolid technique, Biopharmaceutics classification system, Direct compression.