Abstract

EVALUATION OF ANTI-ANXIETY ACTIVITY OF BARRINGTONIA RACEMOSA SEEDS

Saloni Chourasia*, Sakshi Ahirwar, Asha Rani Pyati, Namrata Gupta,
Anant Kumar Patel and Sandhya Sujane

ABSTRACT

Introduction:- In one word, we can say that anxiety is a feeling of fear. The object of fear may be true orthat may be just an imagination, often general causes of anxiety are - tension of examination, arrangement of money for survival of family, the incident that had already happened, fear to stand in front of crowd, and speaking among them. Worries, doubt, and fear are a normal part of life. It is natural to be anxious about our upcoming test or to worry about our financial condition. The difference between normal worrying and generalized anxiety disorder is that generalized anxiety is excessive, intrusive, persistent, and debilitating. In animal model study, it has been seen that height, hunger, loneliness, disease, thrust, threatening condition, violence, pain, darkness, and different stimulus such as current, heat, cold, pinch, and self-image are used for the development of anxiety. Thus, different models that have been made by researchers are based on different principle and methodology so we cannot judge the efficacy of any reference or experimental drug. One common principle among all of these models is that they are basedon the behaviour of experimental animal. Material & Methods:- The antianxiety activity of methanolic extract of Barringtonia racemosa seeds were tested by Elevated Plus maze test model in Albino mice. Animals were divided into 4 groups, eachgroup contain 6 animals and orally administered with Normal Saline, Standard Drug, Test 1 and Test 2 drug. Duration of immobility was observed for 5 minutes. Results:- It has been observed from our study that both the doses Test 1 (150 mg/kg) and Test 2 (300mg/kg) showed significant ( P<0.05) anti-anxiety activity in Elevated Plus maze test model. In these animal model, the anxiety-related behaviors in mice were significantly decreased indicates that anxiety in mice was relieved after treatment with extract. Conclusion:- The methanolic extract of seeds of Barringtonia racemosa has significant antianxiety activity in acute animal models for anxiety.

Keywords: Anti-anxiety, Barringtonia racemosa, Putat, Plus maze test model, Jungli Badam, Lorazepam.