Abstract

RECENT ADVANCEMENT IN GEL FORMULATION: A REVIEW

Sonam Thakur, Archana Chaudhary*, Vinay Pandit and Tarun Kumar

ABSTRACT

Transdermal drug delivery systems are a constant source of interest due to various advantages it provides in overcoming many drawbacks associated with other modes of drug delivery (e.g., intravenous, oral). Because of their ease of use and improved percutaneous absorption, topical gels are becoming more popular. Gels are semi-solid formulations with a hydrophobic or hydrophilic outer solvent stage that are immobilised within a three-dimensional network structure. In topical administration, gel formulations give improved application properties and stability. Topical gels should be used on skin, or on some mucosal surfaces, for local activity or percutaneous drug penetration, as well as for emollient or protective action. Other types of gels for cutaneous medication delivery, such as proniosomal gels, emulgels, bigels, and aerogels, have been documented in recent investigations. Over the last decade, in situ gelling drug delivery systems have received a lot of attention. It is in a sol-state prior to administration and can form gels in response to endogenous stimuli such as temperature increase, pH change, and the presence of ions. Such systems can be administered in a variety of ways to achieve local or systemic drug delivery.[2]

Keywords: Transdermal, Drug Delivery, Percutaneous, Topical Gels, Hydrophilic, Hydrophobic, Immobilized, Skin, Endogenous stimuli, pH, Administered.