Abstract

BIOLOGICAL ACTIVITY OF MANNICH BASES: A REVIEW

Priya H. Rahangdale*, Pallavi Syamkuwar, Gagan Bopche, Poonam Rahangdale, Payal Yele, Pallavi Katre and Vikas Turkar

ABSTRACT

The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various reactants through the addition of aminomethyl function it means the Mannich reaction. Mannich bases are the products of Mannich reaction. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a important step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the building of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, with high curative value. The review covers extensively the literature reports that have elaborate Mannich bases as anticancer and cytotoxic agents, or compounds with potential antibacterial and antifungal activity in the last decade. The most relevant studies on the activity of Mannich bases as antimycobacterial agents, antimalarials, or antiviral candidates have been incorporated as well. The review contains also a thorough coverage of anticonvulsant, anti-inflammatory, analgesic and antioxidant activities of Mannich bases. In addition, several minor biological activities of Mannich bases, such as their ability to regulate blood pressure or inhibit platelet aggregation, their antiparasitic and anti-ulcer effects, as well as their use as agents for the treatment of mental disorders have been accessible. The review gives in the end a brief overview of the potential of Mannich bases as inhibitors of various enzymes for several receptors.

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