Abstract

THE COMPOUND IN BOESENBERGIA PANDURATA RHIZOME AS HIV-1 PROTEASE INHIBITOR: IN-SILICO STUDY

Resmi Mustarichie*, Sandra Megantara and Ike Susanti

ABSTRACT

HIV is a major source of public health problems globally and has claimed an estimated 33 million people. There are more than 20 compounds of the terpenes and sterols that are useful as anti-HIV agents that can be studied to see if they are bound to the HIV-1 receptor compounds. In this article, we report in-silio study of the compounds of Boesenbergia pandurata as HIV-1 Protease inhibitor and result is that 4-Hydroxypanduratin and panduratin A as a good candidate for HIV-1 treatment by using autodock and pre-ADMET method.

Keywords: In-silico, Boesenbergia pandurate, HIV-1, Protease inhibitor, ADMET